TOPS logo (red apple is the letter o), image of a knee. THE OSTEOARTHRITIS PREVENTION STUDY

Principal Investigator:

Stephen P. Messier, PhD

Objective:

The objective of this Phase III, multi-site (Boston, MA, Chapel Hill, NC, Sydney, Australia, and Winston-Salem, NC) randomized clinical trial is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee OA prevention.

Site Principal Investigators:

Wake Forest University logo

Site PI: Shannon Mihalko, PhD

Site PI: Elena Losina, PhD, MSc

UNC Chapel Hill logo

Site PI: Leigh Callahan, PhD

Wake Forest University School of Medicine logo

Data Coordinating Center: Edward Ip, PhD

University of Sydney logo

Site PI: David Hunter, MD

University of Missouri Mizzou logo

Data Coordinating Center: Jimi Cook, DVM, PhD, OTSC

Co-Investigators:

Ali Guermazi, MD, PhD, Jeffery Katz, MD, MSc, Emily Leary, PhD, Richard Loeser Jr., MD, Gary Miller, R.D. PhD, Brian Pietrosimone, PhD, ATC, Sandra Soto, PhD, Kurt Spindler, MD, Ezequiel Zamora, MD

Interested in Participating?

Study participants receive, at no cost:

You may qualify to participate if you: 

Contact us:

To learn more, please call 877-238-4825, option 6; email us at tops@wfu.edu;
or visit https://redcap.link/jp42mvpo to see if you qualify

Funding Sources:

NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases logo
Arthritis Foundation logo