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  HES: Current Research Activities  
 
 
 
Study Faculty Description Status Recent Publications

HELP PD

Healthy Living Partnership to Prevent Diabetes

Sponsor

NIDDK

Katula

The overall goal is to translate knowledge regarding the prevention of type 2 DM into practice in the community.  This project is testing the effectiveness of a group-based intensive lifestyle behavioral intervention led by community health workers delivered in the community via an existing Diabetes Care Center (DCC) in preventing the onset of type 2 DM.

Data Collection Ongoing

Katula et al. (2009)

HF ACTION

Heart Failure:  A Controlled Trial Investigating Outcomes In Heart Failure

Sponsor

NIH

Brubaker

The major goal of this large, multicenter trial is to determine if exercise training reduces the morbidity and mortality associated with heart failure

Baseline data collection completed and analyses ongoing

O’Connor et al. (2009)

Flynn et al. (2009)

IDEA

Intensive Diet and Exercise for Arthritis

Sponsor

NIAMS

Messier

Mihalko

Miller

The primary aim is to compare the effects of intensive diet and exercise, both alone and in combination, on potential mechanisms associated with the OA disease pathway, inflammation and knee joint loads.  Secondary aims are: to compare the effects of these interventions on self-reported function and pain, and mobility; to determine the dose response to weight loss on disease progression; to determine if inflammatory biomarkers and knee joint loads significantly effect function, pain, and disease progression; and to determine the association between quadriceps strength and disease progression as a function of knee alignment.

Data Collection Ongoing

Messier et al. (2009)

LIFE-P

Lifestyle Interventions and Independence For Elders-Pilot

Sponsor

NIA

Rejeski

Katula

Marsh

Brubaker

The major goal of this project is to gather preliminary data that will determine the feasibility of conducting a Phase 3 randomized, controlled trial (RCT) that will provide definite evidence in the use physical exercise to prevent physical and mobility disability in older persons.

Data collection completed; Analyses ongoing;

Main trial under review at NIA

Manini et al. (2009)

Kwon et al. (2009)

Rejeski et al. (2009)

Rejeski et al. (2008)

Rejeski et al. (2008)

Rejeski et al. (2007)

Fielding et al., (2007)

Katula et al. (2007)

Groessl et al. (2007)

The LIFE Study Investigators (2006)

Rejeski et al. (2005)

LookAHEAD

Action for Health in Diabetes

Sponsor

NIDDK

Rejeski

Miller

Ribisl

Look AHEAD is a multicenter randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. It is focused on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease.

Data Collection Ongoing; analyses ongoing.

Espeland et al. (2009)

Williamson et al. (2009)

Ribisl et al. (2007)

Rejeski et al. (2006)

Wadden et al. (2006)

PEPC

Prenatal Exposures/ Postnatal Events:  Antenatal Steroids and Blood Pressure in Childhood

Sponsor

NICHD

Nixon

The major goal of this project is to examine the effects of antenatal steroid exposure on blood pressure levels and mechanisms of blood pressure regulation in adolescents born prematurely with very low birth weight

Data collection ongoing

Nixon et al. (2007)

O’Shea et al. (2007)

Washburn et al. (2006)

REACT II

Reconditioning Exercise And COPD Trial II

Sponsor

NHLBI

Berry

Rejeski

Katula

The goal of this project is to compare traditional short-term exercise therapy to a theoretically-driven lifestyle activity intervention on long-term maintenance of physical activity in persons with COPD.

Data Collection Completed; Analyses Ongoing

Berry et al. (In press)

Berry (2007)

Berry et al. (2006)

Foy et al. (2006)

TARGET

Trial with Acute Respiratory failure patients: evaluation of
Global Exercise Therapies

Sponsor:

NINR

NHLBI

Berry

The goal of this project is to determine the efficacy of a comprehensive exercise therapy program at reducing hospital length of stay and improving physical function in acute respiratory failure patients on mechanical ventilation.

Data collection beginning.  Contact Jordan Irwin for more information (irwinje@wfu.edu)

Morris et al.(2008)

BASS

Be A Smart Shopper

Sponsor

Pro Humanitate Fund

Miller

The goal of this project is to examine the impact of a novel supermarket led nutrition education program on knowledge and behaviors in grade school children

Data Collection Ongoing

CLIP

Cooperative Lifestyle Intervention Program

Sponsor

NHLBI

Rejeski

Brubaker

CLIP is examining the effect of physical activity only, a combination of physical activity and weight loss, or successful aging education on mobility disability. We are currently recruiting adults 60-79 years of age who are overweight and have a history of cardiovascular disease or the metabolic syndrome to participate.

Data Collection Ongoing

DCIS

A Pilot Study in Women with Ductal Carcinoma in Situ

Sponsor

Piedmont Alliance for Cancer Research and Education Fund

Mihalko

The purpose of this study is to describe the physical functioning and health-related quality of life (HRQL) of women recently treated for DCIS and to determine if a moderate, tailored exercise intervention, as compared to enhanced usual care, significantly improves physical outcomes, including cardiorespiratory endurance, muscular strength and flexibility, and HRQL in women with DCIS. In addition, this study will make possible a comparison of DCIS participants with women diagnosed with stage I-III breast cancer who have been recruited for our larger prospective trial to describe differences in outcome measures by severity of diagnosis, as well as differential effect of the exercise intervention.

Data collection completed; Analyses ongoing

Look AHEAD – Weight Reduction and Function

Sponsor:

NIA

Miller

This ancillary study to Look AHEAD is examining the effect of weight loss and physical activity on physical function and cognition in individuals with type 2 diabetes undergoing behavioral lifestyle changes to reduce weight.

Data collection ongoing

LOSE IT

Laparoscopic Obesity Surgery

Sponsor

Pepper Pilot Project

Miller

The goal of this observational study is to examine the impact of extreme weight loss for 1 year following laparoscopic Roux-en-Y gastric bypass surgery on inflammation, physical function, and body composition

Data Collection Ongoing

Nitric Oxide and Functional Health

Sponsor:

Science Research Fund

Miller

Rejeski

Marsh

Brubaker

The goal for this study is to examine the impact of dietary nitrates on nitrogen containing metabolites in the blood and the subsequent effect on metabolism and cognition

Data collection and intervention beginning

PCOS

Sponsor:

WFU Cross Campus Collaborative Grant

Miller

This study is investigating the effect of exercise training on hormone changes in women with polycystic ovary syndrome (PCOS).

Data collection and intervention beginning

REACT III-p

Reconditioning Exercise And COPD Trial

Sponsor: Translational Science Institute, WFU Pepper Center

Berry

The goal of this project is to collect pilot data regarding the efficacy of a strength training program in persons with COPD.

Data collection on-going.  Contact Jordan Irwin for more information (irwinje@wfu.edu)

RESET

Restoration of Chronotropic Competence in Heart Failure Patients with Normal Ejection Fraction

Sponsor

Boston -Scientific

Brubaker

Core-laboratory for cardiopulmonary exercise testing outcomes from multi-center trial

Data Collection ongoing

RESTORE

 

Research on Optimal Recovery Practices in Breast Cancer

Sponsor

Department of Defense

Mihalko

Ribisl

The purpose of this study is to examine the influence of an exercise intervention on physical and psychosocial health outcomes in breast cancer survivors.  Specifically, intervention effects on self-efficacy, quality of life and functional outcomes will be determined. Additionally, adherence to the physical activity program will be examined at 18-months of follow-up.

Data collection completed; Analyses ongoing

SHARP-P

Senior Health and Activity Research Program-Pilot

Sponsor

NIA

Rejeski

Katula

The goal of the project is to develop and conduct a randomized clinical trial to assess whether a multi-factorial intervention involving physical activity and cognitive training reduces the risk of significant cognitive decline in older individuals.

Data Collection ongoing

 
 
 

Wake Forest University, Health and Exercise Science Dept.
PO Box 7868, Winston-Salem, NC 27109
p: 336-758-5391 | f: 336-758-4680

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